Research signals.

Pyrite: Building and Benchmarking Protein-Ligand Pose Ranking Agents

Predicting how a ligand binds to its target is central to small-molecule drug discovery. Modern cofolding models can generate diverse candidate poses, but reliably ranking these candidates remains…

Continual-ARC: Measuring Skill Acquisition over a Working Lifetime

Agent harnesses have emerged as a promising mechanism for continual learning, alongside test-time parametric learning. However, the current benchmarks have several limitations: they generally focus…

Comparative Analysis of Agent Evaluation Frameworks: Stability, Detection, and Discovery in Enterprise Analytics Agents

Deploying LLM-based analytics agents in enterprise settings requires evaluation frameworks that can reliably detect failures across complex, multi-tool workflows. We present a three-phase comparative…

ReTrace: Distilling Tool-Using Agents into Planner-Free Workflows

Business process automation runs the same Standard Operating Procedure (SOP) again and again on new inputs. Large Language Model (LLM) agents can follow an SOP written in natural language, but they…

ScrapeBench: Evaluating Legal Compliance of AI Agents in Website Scraping

AI agents deployed on the open web are becoming more capable of performing actions that may breach contractual provisions and violate computer security laws. In this paper, we introduce ScrapeBench,…

FAME-QP: A GPU-Accelerated Quadratic-Programming Solver for Real-Time Model Predictive Control

We present FAME-QP, a GPU-accelerated solver for dense quadratic programs arising in linear model predictive control. FAME-QP combines constraint-dependent operator representations with fused single-…

Introducing Gemini 4 Hydrogen

AlphaGenome 2: Deciphering how cells read DNA to better understand disease

Predicting how DNA sequences and their variations impact specific human cell types and disease.

Holiday Extras is rethinking what it can build with Codex

With Codex, Holiday Extras is turning customer expertise into better apps, higher booking conversion and new possibilities for growth.

Supporting research on AI and children’s safety

OpenAI commits $2 million to research on AI and children’s safety. The work supports shared tools to measure risks and opportunities for young people.

Gemini Decisions API

Gemini Decisions API Google join Jev and OpenAI in the decision model category with "Gemini Decision 1". This new model API is almost identical to Jev: it supports the same three types of questions…

llm 0.37.2

Release: llm 0.37.2 Fixes a security issue reported by Daniel de Araujo in GHSA-v9h7-jj4g-f862 and GHSA-r639-rr7r-x72w . LLM has a mechanism called extra-openai-models.yaml - now managed by the…

The Definitive Fine-Tuning Guide for 3D Generation Models

BotPsy: On-Device Personal Assistant with a Sub-Billion-Parameter Agentic Language Model

Delaying Internal Deployments Until After X Days of Safety Testing

This post reflects my own takes, and not that of my employer's. This is a simple idea: before a new model can be deployed internally, you must first test it for a minimum, fixed period. You can…

Q3.5 Timelines Update: Looks Like the Intelligence Explosion Will Happen in 2027 After All

We want to get this post out quickly given the urgency of the topic. It’s possible that there are some errors in the modeling, but we think it’s very unlikely that they undermine the high level…

Your AI agent fixed the bug, but what else did it change?

Today we’re publishing patching-bugs and regression-hunt , two plugins that let engineers delegate patch development and regression checks to agents. Our patching-bugs plugin reproduces reported…

Auditing in the age of (good enough) AI

Security firms have published numerous blog posts describing how they pointed their agent harness at a codebase and found dozens of bugs ( we’re one of them ). However, these posts tend to focus on…

The Sequence Learning Loop - Issue #969: Last Week in AI: Security Agents, Custom Models, and Editable Video

GPT-6 Cyber, Inkling 2 Small, and Gemini put feedback at the center of useful work

Import AI 480: Self-sustaining space economies; AI for science progress, and Meta builds perfect hands for a superintelligence

When do you think we'll have robots on the moon?

Mathematics Just Changed Forever — Kevin Hartnett

Kevin Hartnett is the author of *The Proof in the Code*.SPONSOR:---Cyber Fund built the Monastery to help founders ship products that were impossible a year ago. Applications for Batch 1 are now…

How big is the open model economy today?

Our first open model economy research note for paid subscribers.

The Download: Pelosi’s successor targets AI and data centers face power woes

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Nancy Pelosi’s replacement is ready to regulate AI —Grace…